Katelyn Boese

My broad research interest is exploring how biological factors beyond DNA itself, such as evolutionary pressures and epigenetic state, act to shape the dynamic process of genetic inheritance across cell generations. I am currently working on a project in the Lampson Lab related to a specific epigenetic marker called CENP-A. Nucleosomes containing this histone variant are essential for faithful chromosome segregation because they are the primary determinant of the centromere locus. In mammalian oocytes, these CENP-A nucleosomes must be preserved during a prolonged meiotic prophase arrest in order to form viable gametes after meiotic resumption. Using a mouse model, I aim to clarify the mechanisms underlying CENP-A nucleosome persistence in prophase-arrested mammalian oocytes. These results will contribute to scientific understanding of how this important epigenetic protein mark is inherited through the germline. In addition to pursuing research as a Biology major, I am also working on a major in Classical Studies and enjoy making music with the Penn Band and Wind Ensemble. I would be happy to further discuss my research experience, projects, or other activities, so please feel free to reach out with any questions you may have.

• University Scholars C'23 
• Research Assistant in Lampson Lab (2019 - present)